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Dear All,</div>
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Consider attending the Clinical Center Grand Rounds tomorrow at noon. More information below:</div>
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<span style="font-family: Aptos, Arial, Helvetica, sans-serif; font-size: 14pt; color: black;"><b>NIH Clinical Center Grand Rounds, Tomorrow, Wednesday, Dec. 17, 2025</b></span><span style="font-family: Aptos, Arial, Helvetica, sans-serif; font-size: 14pt; color: navy;"><b>,</b></span><span style="font-family: Aptos, Arial, Helvetica, sans-serif; font-size: 14pt; color: rgb(0, 0, 0);"><b> 12
pm - 1 pm</b></span><span style="font-family: Aptos, Arial, Helvetica, sans-serif; font-size: 14pt; color: black;"><b>,
</b></span><span style="font-family: Aptos, Arial, Helvetica, sans-serif; font-size: 14pt; color: rgb(0, 0, 0);"><b>live in Lipsett Amphitheater and on NIH Videocast
</b></span><span style="font-family: "Times New Roman", serif; font-size: 14pt; color: rgb(150, 96, 125);"><b><a href="https://urldefense.com/v3/__https://links-2.govdelivery.com/CL0/https:*2F*2Fvideocast.nih.gov*2Fwatch=57133/1/0101019b27e6ce34-2076646b-8a9b-4648-9032-e89e9ef483aa-000000/GuylMy7ltG1vVAZyAqg53DXr-PDDugBXeoyg1a_9TX4=435__;JSUl!!GobTDDpD7A!Iv5ncK3tuedbKzQEcJJQsexp6UkBxTfqFV9xhxbcb4Psa4_OODmHSBlHnqVXu3tadj9QLmsc-YEM7sKj-i-1rQxc-RY$" title="https://videocast.nih.gov/watch=57133" data-outlook-id="e1d190a5-0f67-4477-bb61-b01224f461cf" style="color: rgb(150, 96, 125); margin-top: 0px; margin-bottom: 0px;">https://videocast.nih.gov/watch=57133</a></b></span></p>
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<span style="font-family: arial, helvetica, sans-serif; font-size: 24px; color: rgb(0, 0, 128);"><b>Topic: </b></span></p>
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<span style="font-family: "Times New Roman", serif; font-size: 14pt; color: rgb(33, 33, 33);"><b>Harnessing The Extracellular Matrix to Treat Lung Diseases</b></span></p>
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<span style="font-family: Aptos, sans-serif; font-size: 11pt; color: rgb(33, 33, 33);"> </span></p>
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<span style="font-family: arial, helvetica, sans-serif; font-size: 24px; color: rgb(0, 0, 128);"><b>Presenter:</b></span></p>
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<span style="font-family: Aptos, sans-serif; font-size: 11pt; color: rgb(33, 33, 33);"> </span></p>
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<span style="font-family: "Times New Roman", serif; font-size: 14pt; color: rgb(33, 33, 33);"><b>Stavros Garantziotis, MD</b></span></p>
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<span style="font-family: "Times New Roman", serif; font-size: 16px; color: rgb(33, 33, 33);">Investigator</span></p>
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<span style="font-family: "Times New Roman", serif; font-size: 16px; color: rgb(33, 33, 33);">Immunity, Inflammation, and Disease Laboratory/Matrix Biology Group</span></p>
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<span style="font-family: "Times New Roman", serif; font-size: 16px; color: rgb(33, 33, 33);">National Institute of Environmental Health Sciences</span></p>
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<span style="font-family: Aptos, sans-serif; font-size: 16px; color: rgb(33, 33, 33);"> </span></p>
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<p style="margin: 0in; font-family: Calibri, sans-serif; font-size: 11pt;"><span style="font-family: Aptos, sans-serif; font-size: 9pt;">--------- </span></p>
<p style="margin: 0in;"><span style="font-size: 11pt; color: black;"><b>Dimitra Bourboulia, PhD, SFCSSI</b></span></p>
<p style="margin: 0in;"><span style="font-size: 10pt; color: black;"><b>Associate Professor, Department of Urology</b></span></p>
<p style="text-align: left; margin: 0in;"><span style="font-size: 9pt; color: black;">Assistant Dean for UME and GME Research</span></p>
<p style="text-align: left; margin: 0in;"><span style="font-size: 9pt; color: black;">Director, Office of Research for Medical Students</span></p>
<p style="text-align: left; margin: 0in;"><span style="font-size: 9pt; color: black;"><br>
</span></p>
<p style="margin: 0in; font-family: Calibri, sans-serif; font-size: 11pt;"><span style="font-family: Aptos, sans-serif; font-size: 8pt; color: black;"><b>Editor in Chief</b></span></p>
<p style="margin: 0in; font-family: Calibri, sans-serif; font-size: 11pt;"><span style="font-family: Aptos, sans-serif; font-size: 8pt; color: rgb(5, 99, 193);"><b><u><a href="https://urldefense.com/v3/__https://www.sciencedirect.com/journal/cell-stress-and-chaperones/about/aims-and-scope__;!!GobTDDpD7A!JCxxa0Z79_ghuANDhOglRVsGIoaEN6-1DcY0Q6LUm0Sa8zRZTrImx51itTPGeU1KWP00ib6MVMPOUY__eNWcm8p2S0vKiQ$" data-outlook-id="9e6afd81-7e90-45d1-a6a9-f5642858ff72" style="margin-top: 0px; margin-bottom: 0px;">Cell
Stress and Chaperones</a></u></b></span><span style="font-family: Aptos, sans-serif; font-size: 8pt; color: black;"><b> (published with Elsevier)</b></span></p>
<p style="margin: 0in; font-family: Calibri, sans-serif; font-size: 11pt;"><span style="font-family: Aptos, sans-serif; font-size: 8pt;"><b>ISSN: 1355-8145</b></span></p>
<p style="margin: 0in; font-family: Calibri, sans-serif; font-size: 11pt;"><span style="font-size: 8pt; color: rgb(5, 99, 193);"><b><u><a href="https://urldefense.com/v3/__https://cellstressresponses.org/__;!!GobTDDpD7A!JCxxa0Z79_ghuANDhOglRVsGIoaEN6-1DcY0Q6LUm0Sa8zRZTrImx51itTPGeU1KWP00ib6MVMPOUY__eNWcm8q60-n8Tg$" data-outlook-id="f0658e38-56e7-4dd2-84be-e80a4ea17a97" style="margin-top: 0px; margin-bottom: 0px;">Cell
Stress Society International</a></u></b></span></p>
<p style="margin: 0in; font-family: Calibri, sans-serif; font-size: 11pt;"><span style="font-family: Aptos, sans-serif; font-size: 8pt;"> </span></p>
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<b>From: </b>NIH Clinical Center <NIHCC@public.govdelivery.com><br>
<b>Date: </b>Tuesday, December 16, 2025 at 11:03 AM<br>
<b>To: </b>Dimitra Bourboulia <BourmpoD@upstate.edu><br>
<b>Subject: </b>[EXTERNAL] Tomorrow: CC Grand Rounds Dec. 17 at Noon: Harnessing The Extracellular Matrix to Treat Lung Diseases<br>
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<p class="ms-outlook-mobile-reference-message skipProofing"><span style="font-size: 14pt; color: black;"><b>NIH Clinical Center Grand Rounds, Tomorrow, Wednesday, Dec. 17, 2025</b></span><span style="font-size: 14pt; color: navy;"><b>,</b></span><span style="font-size: 14pt; color: rgb(0, 0, 0);"><b> 12
pm - 1 pm</b></span><span style="font-size: 14pt; color: black;"><b>, </b></span><span style="font-size: 14pt;"><b>live in
</b></span><span style="font-size: 14pt; color: rgb(0, 0, 0);"><b>Lipsett Amphitheater
</b></span><span style="font-size: 14pt;"><b>and on NIH Videocast </b></span><span style="font-family: "Times New Roman", serif; font-size: 14pt; color: rgb(150, 96, 125);"><b><a href="https://urldefense.com/v3/__https://links-2.govdelivery.com/CL0/https:*2F*2Fvideocast.nih.gov*2Fwatch=57133/1/0101019b27e6ce34-2076646b-8a9b-4648-9032-e89e9ef483aa-000000/GuylMy7ltG1vVAZyAqg53DXr-PDDugBXeoyg1a_9TX4=435__;JSUl!!GobTDDpD7A!Iv5ncK3tuedbKzQEcJJQsexp6UkBxTfqFV9xhxbcb4Psa4_OODmHSBlHnqVXu3tadj9QLmsc-YEM7sKj-i-1rQxc-RY$" title="https://videocast.nih.gov/watch=57133" data-outlook-id="e1d190a5-0f67-4477-bb61-b01224f461cf" style="color: rgb(150, 96, 125); margin-top: 0px; margin-bottom: 0px;">https://videocast.nih.gov/watch=57133</a></b></span></p>
<p class="ms-outlook-mobile-reference-message skipProofing"><span style="font-family: arial, helvetica, sans-serif; font-size: 24px; color: rgb(0, 0, 128);"><b>Topic: </b></span></p>
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<span style="font-family: "Times New Roman", serif; font-size: 14pt;"><b>Harnessing The Extracellular Matrix to Treat Lung Diseases</b></span></p>
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</p>
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<span style="font-family: arial, helvetica, sans-serif; font-size: 24px; color: rgb(0, 0, 128);"><b>Presenter:</b></span></p>
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</p>
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<span style="font-family: "Times New Roman", serif; font-size: 14pt;"><b>Stavros Garantziotis, MD</b></span></p>
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<span style="font-family: "Times New Roman", serif;">Investigator</span></p>
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<span style="font-family: "Times New Roman", serif;">Immunity, Inflammation, and Disease Laboratory/Matrix Biology Group</span></p>
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<span style="font-family: "Times New Roman", serif;">National Institute of Environmental Health Sciences</span></p>
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</p>
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<span style="font-family: arial, helvetica, sans-serif; font-size: 24px; color: rgb(0, 0, 128);"><b>Lecture Summary:</b></span></p>
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</p>
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<span style="font-family: "Times New Roman", serif;">Environmental lung injury is the cause of most lung diseases. However, studying the thousands of exposures that may impact lung health is not easy. This lecture proposes a new mechanistic approach, i.e.,
that microenvironmental changes in the extracellular matrix mediate environmental lung injury. Preclinical and clinical studies will be presented, that support the use of novel, extracellular matrix-targeting agents as viable therapeutics in lung disease.</span></p>
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<span style="font-family: "Times New Roman", serif;"> </span></p>
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<span style="font-family: "Times New Roman", serif;">The lecture will be broadcast at
</span><span style="font-family: "Times New Roman", serif; color: rgb(150, 96, 125);"><a href="https://urldefense.com/v3/__https://links-2.govdelivery.com/CL0/https:*2F*2Fvideocast.nih.gov*2Fwatch=57133/2/0101019b27e6ce34-2076646b-8a9b-4648-9032-e89e9ef483aa-000000/TrN4gyBN14cCXMEuguKcq11TKRCZMKRK5PM7srY9x-8=435__;JSUl!!GobTDDpD7A!Iv5ncK3tuedbKzQEcJJQsexp6UkBxTfqFV9xhxbcb4Psa4_OODmHSBlHnqVXu3tadj9QLmsc-YEM7sKj-i-1lRWLIAQ$" title="https://videocast.nih.gov/watch=57133" data-outlook-id="4fd176b0-06d8-4d48-9fb1-b016a57f8387" style="color: rgb(150, 96, 125); margin-top: 0px; margin-bottom: 0px;">https://videocast.nih.gov/watch=57133</a></span><span style="font-family: "Times New Roman", serif;"> and
archived for future viewing. </span></p>
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<span style="font-family: "Times New Roman", serif;"> </span></p>
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<span style="font-family: "Times New Roman", serif; font-size: 12pt;">NIH Clinical Center Grand Rounds is a weekly CME activity showcasing a wide variety of topics from a diverse group of speakers to help those in attendance stay current on the latest advances
in medicine and to assist them in their continued professional growth. </span></p>
<p class="x_paragraph">Continuing Medical Education (CME) code is posted at the beginning and end of the lecture. </p>
<p class="x_paragraph"><b><u>Continuing Medical Education (CME) </u></b></p>
<p class="x_paragraph"> NIH Clinical Center Grand Rounds is a weekly CME activity that offers its audience a wide variety of topics from a diverse group of speakers, to not only help them remain current on the latest advances in medicine, but to also assist
them as they continue to grow professionally. </p>
<p class="x_paragraph">· To Claim CME, text the CME code to Hopkins the CME Number </p>
<p class="x_paragraph">· <b>IMPORTANT: Hopkins has updated the number you text for CME. Text your CME Code to (844) 980-1555 (new number)</b> </p>
<p class="x_paragraph">· The CME code is posted at the beginning and end of each CC Grand Rounds </p>
<p class="x_paragraph">· If this is your first time claiming CME you must first set up an account on the Hopkins Cloud CME website, then pair your mobile phone with your account before you text the code </p>
<p class="x_paragraph">· You can text to claim credit for CC Grand Rounds until 8 pm on Wednesdays </p>
<p class="x_paragraph">· You can also claim credit by going to the Hopkins Cloud CME website </p>
<p class="x_paragraph">· If you need the code or have questions, email CME Administrator Rita Stevens at
<a href="mailto:rita.stevens@nih.gov" data-linkindex="1" data-outlook-id="26b846f7-994d-4ade-a76f-209fc856ec20" style="margin-top: 0px; margin-bottom: 0px;">
rita.stevens@nih.gov</a> </p>
<p class="x_paragraph"> <b>CME ACCREDITATION STATEMENT</b> </p>
<p class="x_paragraph">The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. </p>
<p class="x_paragraph"><b>CREDIT DESIGNATION STATEMENT</b> </p>
<p class="x_paragraph">The Johns Hopkins University School of Medicine designates this regularly scheduled series- live activity for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation
in the activity. This series has been approved for a 52-week cycle beginning September 6, 2023 and ending September 6, 2024. </p>
<p class="x_paragraph"><b>POLICY ON PRESENTER AND PROVIDER DISCLOSURE</b> </p>
<p class="x_paragraph">It is the policy of the Johns Hopkins University School of Medicine that the presenter and provider globally disclose conflicts of interest and any discussion of unlabeled/unapproved uses of drugs or devices during their presentation(s).
The Johns Hopkins University School of Medicine OCME has established policies in place that will identify and resolve conflicts of interest prior to this educational activity. Detailed disclosure will be made prior to presentation of the education. </p>
<p class="x_paragraph"><b>FULL DISCLOSURE POLICY AFFECTING CME ACTIVITIES</b> </p>
<p class="x_paragraph">As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), John Hopkins University School of Medicine Office of Continuing Medical Education (OCME) requires attested and signed global disclosure of the
existence of all financial interests or relationships with commercial interest from any individual in a position to control the content of a CME activity sponsored by OCME. </p>
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