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<span style="margin:0px;font-size:12pt"></span><span style="margin:0px;font-size:12pt;font-family:Calibri, sans-serif"> NYC PCC Grand Rounds and Consultants' Conference in March 2021.</span></p>
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<span style="margin:0px;font-size:10pt;font-family:Calibri, sans-serif"><span style="margin:0px;font-size:12pt"><font size="3" face="Calibri,Helvetica,sans-serif" color="black" style="font-family:Calibri, Helvetica, sans-serif, serif, EmojiFont"><span style="margin:0px"><font color="black"><font size="3" face="Calibri,Helvetica,sans-serif" color="black"><span style="margin:0px"></span></font></font></span></font></span></span></p>
<div style="margin:0px"><font size="3" face="Calibri,Helvetica,sans-serif" color="black" style="font-family:Calibri, Helvetica, sans-serif, serif, EmojiFont"><font color="black"><font size="3" face="Calibri,Helvetica,sans-serif" color="black"><font size="3" face="Times New Roman,Times,serif" style="font-family:"Times New Roman", Times, serif, serif, EmojiFont">Our
 grand rounds speaker will be<span> </span><span style="margin:0px;font-size:10pt;font-family:Calibri, sans-serif"><span style="margin:0px;font-size:12pt"><font size="3" face="Calibri,Helvetica,sans-serif" color="black" style="font-family:Calibri, Helvetica, sans-serif, serif, EmojiFont"><span style="margin:0px"><font color="black"><font size="3" face="Calibri,Helvetica,sans-serif" color="black"><span style="margin:0px"><font size="2" face="Times New Roman,Times,serif" style="font-family:"Times New Roman", Times, serif, serif, EmojiFont"><span style="margin:0px;font-size:11pt"></span></font></span></font></font></span></font></span></span><span style="margin:0px">Konstantin
 Ichtchenk<font face="Times New Roman,Times,serif">o and the title of his talk is: <span style="margin:0px;font-size:10pt;font-family:Calibri, sans-serif"><span style="margin:0px;font-size:12pt"><font size="3" face="Calibri,Helvetica,sans-serif" color="black" style="font-family:Calibri, Helvetica, sans-serif, serif, EmojiFont"><span style="margin:0px"><font color="black"><font size="3" face="Calibri,Helvetica,sans-serif" color="black"><span style="margin:0px"><font size="2" face="Times New Roman,Times,serif" style="font-family:"Times New Roman", Times, serif, serif, EmojiFont"><span style="margin:0px;font-size:11pt">“</span></font><font size="3" face="Times New Roman,Times,serif" style="font-family:"Times New Roman", Times, serif, serif, EmojiFont"><span style="margin:0px">Neuronal
 Delivery Of Therapeutic Antibodies For Treatment Of Botulism.”</span></font></span></font></font></span></font></span></span></font></span></font></font></font></font></div>
<span style="margin:0px;font-size:10pt;font-family:Calibri, sans-serif"><span style="margin:0px;font-size:12pt"><font size="3" face="Calibri,Helvetica,sans-serif" color="black" style="font-family:Calibri, Helvetica, sans-serif, serif, EmojiFont"><span style="margin:0px"><font color="black"><font size="3" face="Calibri,Helvetica,sans-serif" color="black"><span style="margin:0px">
<div align="justify" style="margin:0px"><font size="3" face="Times New Roman,Times,serif" style="font-family:"Times New Roman", Times, serif, serif, EmojiFont"><span style="margin:0px"><br>
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<div align="justify" style="margin:0px"><font size="3" face="Times New Roman,Times,serif" style="font-family:"Times New Roman", Times, serif, serif, EmojiFont"><span style="margin:0px">Bio: Dr. Ichtchenko scientific interests are centered on understanding the
 molecular mechanisms controlling exocytosis and endocytosis at nerve termini, and in designing molecular tools that enable the individual steps and components mediating these events to be dissected. He is the Principal Investigator on the funded $7 million
 NIH/NIAID multi-center grant supporting research by developing atoxic Botulinum Neurotoxin (BoNT) derivatives that retain the targeting and intracellular trafficking of wild type BoNT, thereby enabling delivery of the atoxic BoNT light chain (LC) to the neuronal
 cytosol. Dr. Ichtchenko is a widely acknowledged expert on protein engineering, and the molecular mechanisms of inter-neuronal and neuromuscular communication. He was responsible for the first successful expression and crystallographic characterization of
 the LDL receptor extracellular domain, done in collaboration with three Nobel laureates. Dr. Ichtchenko has also made major contributions to the discovery of neuroligins, molecules that are involved in synaptogenesis, and with yet another Nobel laureate, to
 the pre- and post-synaptic mechanisms of action of alpha-latrotoxin (black widow spider toxin). He is currently Assistant Professor in the Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine.</span></font></div>
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 any NYU participants who wish to receive CME credit, please register for the meeting with your NYU email address.
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<p class="x_MsoNormal" style="margin:0in 0in 0in 5.75pt">Thank you very much!</p>
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<p class="x_MsoBodyText" style="margin:11.7pt 5.8pt 0.0001pt 11pt"><span style="margin:0px;font-family:Calibri, sans-serif">Consultants' Conference is a monthly meeting attended by medical toxicologists, emergency physicians, pharmacists and other learners
 from all over the Northeast. It is an educational activity in which the<span> </span><i>Consultants<span> </span></i>(renowned experts in various medical specialties) provide insight into the analysis and approach to the diagnosis and treatment of interesting
 toxicologic cases. The cases are presented mostly by the NYU Toxicology fellows in training, but anyone can present their case if deemed appropriate. Learners of all levels can benefit from the rich and often dynamic discourse.</span></p>
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<span style="margin:0px;font-family:Calibri, sans-serif">The next NYC PCC Grand Rounds and Consultants’ Conference will be held on Thursday, March 4, 2021. Grand Rounds will occur from 1:00 to 1:45 p.m. EST. The topic and speaker will be:</span></p>
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<span style="margin:0px;font-family:Calibri, sans-serif">“<b>Neuronal Delivery of Therapeutic Antibodies for the Treatment of Botulism</b>”</span></p>
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<b><span style="margin:0px;color:black">Konstantin Ichtchenko</span></b></p>
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<b><span style="margin:0px;color:black">Assistant Professor</span></b></p>
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<b><span style="margin:0px;color:black">Department of Biochemistry and Molecular Pharmacology</span></b></p>
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<b><span style="margin:0px;color:black">NYU Grossman School of Medicine</span></b><b><span style="margin:0px;font-family:Calibri, sans-serif;color:black"></span></b></p>
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<span style="margin:0px;font-family:Calibri, sans-serif">Consultants’ Conference will take place shortly after the Grand Rounds lecture is over starting at 2 p.m. EST and ending at 4 p.m. EST.</span></p>
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<span style="margin:0px;font-family:Calibri, sans-serif">We will be broadcasting both the Grand Rounds lecture and Consultants’ Conference via the same link on WebEx and there WILL NOT be a live conference at the Public Health Laboratory. Please click<span> </span><a href="https://urldefense.com/v3/__https://survey.alchemer.com/s3/5971719/Consultant-Conference?eventid=*20a1Q4V00002W4OaXUAV*20&Programname=NYC*20Poison*20Contol*20Center__;JSUlJSU!!GobTDDpD7A!c6fDmBV6uvnPgE0njKgZ56XIUoeyiW790MB_Di0pgy94R_ke7envegc8xarT4BIf$" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" style="margin:0px">here</a><span> </span>to
 register to download the WebEx outlook file.</span></p>
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<b><span style="margin:0px;font-size:10pt;font-family:Calibri, sans-serif">Please Note: If you would like to receive this monthly announcement on a regular basis, please register for the conference at the link above, even if you are unable to attend.</span></b></p>
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<span style="margin:0px;font-family:Calibri, sans-serif">Cases to be discussed for Consultants’ Conference include:</span><b><span style="margin:0px;font-size:14.5pt;font-family:Calibri, sans-serif"></span></b></div>
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<span style="margin:0px;font-family:Calibri, sans-serif"><span style="margin:0px">1.<span style="margin:0px;font:7pt "Times New Roman"">       <span> </span></span></span></span><span style="margin:0px;color:rgb(34, 34, 34);background:white">A 35-year-old male
 patient with no known significant past medical history presents to the ED complaining of palpitations after using an illicit substance. He is admitted to the hospital for persistent altered mental status and a NSTEMI. Three days after hospital admission, he
 is noted to have a flat affect along with increased tone; a medical toxicology consultation is requested by the medical team. His vital signs at this time are: BP, 120/84; HR, 108 beats/min; RR, 18 breaths/minute; T, 35.6°C; O<sub>2</sub> Sat, 99% (RA).</span><span style="margin:0px;font-family:Calibri, sans-serif"></span></p>
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<span style="margin:0px">2.<span style="margin:0px;font:7pt "Times New Roman"">       <span> </span></span></span><span style="margin:0px;color:rgb(34, 34, 34);background:white">A 6-year-old child with prior simple febrile seizures presents to the ED for altered
 mental status after a suspected ingestion of a product being used as a sleep aid. In the ED, the patient is noted to have a 3-minute “seizure-like” event with rigid extremities and drooling, followed by a brief period of unresponsiveness. The child’s vital
 signs after the seizure are: BP, 93/45 mm Hg; HR, 97 beats/minute; RR, 13 breaths/minute; T, 37.6°C, O<sub>2</sub><span> </span>Sat, 98% (room air). </span><br>
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<span style="margin:0px;font-size:13pt"><span style="margin:0px">3.<span style="margin:0px;font:7pt "Times New Roman"">       <span> </span></span></span></span><span style="margin:0px;color:rgb(34, 34, 34);background:white">An 18-year-old female patient presents
 to the ED with altered mental status after an intentional suicidal overdose of her own medications. Her vital signs on presentation are: BP, 156/74 mm Hg; HR, 104 beats/minute; RR, 19 breaths/minute; T, 37.1°C; Os Sat, 100% (room air). Approximately 24 hours
 later, she is noted to have a transient non-sustained wide complex tachycardia seen on telemetry monitoring.</span><span style="margin:0px;font-size:13pt"></span></p>
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<span style="margin:0px;font-family:Calibri, sans-serif">Mark K. Su, MD, MPH</span></p>
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<span style="margin:0px;font-family:Calibri, sans-serif">Director, New York City Poison Control Center</span></p>
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<h1 style="margin:3.8pt 0in 0in 11pt;font-family:"Times New Roman", serif"><span style="margin:0px;font-family:Calibri, sans-serif;color:rgb(33, 33, 33)">Jointly Provided by the NYU Grossman School of Medicine and the Poison Control Center.</span><span style="margin:0px;font-family:Calibri, sans-serif"></span></h1>
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<b><u><span style="margin:0px;font-family:Calibri, sans-serif;color:rgb(33, 33, 33)">Accreditation Statement</span></u></b><b><span style="margin:0px;font-family:Calibri, sans-serif"></span></b></p>
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<span style="margin:0px;font-family:Calibri, sans-serif;color:rgb(33, 33, 33)">This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through
 the joint providership of the NYU School of Medicine and the Poison Control Center. The NYU Grossman School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.</span><span style="margin:0px;font-family:Calibri, sans-serif"></span></p>
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<span style="margin:0px;font-family:Calibri, sans-serif;color:rgb(33, 33, 33)">The NYU Grossman School of Medicine designates both of these as live activities for a maximum of 0.75<span> </span><i>AMA PRA Category 1 Credits</i></span><i><span style="margin:0px;font-size:8pt;line-height:10.3467px;font-family:Calibri, sans-serif;color:rgb(33, 33, 33)">TM<span> </span></span></i><span style="margin:0px;font-family:Calibri, sans-serif;color:rgb(33, 33, 33)">for
 Toxicology Grand Rounds and 2<span> </span><i>AMA PRA Category 1 Credits</i></span><i><span style="margin:0px;font-size:8pt;line-height:10.3467px;font-family:Calibri, sans-serif;color:rgb(33, 33, 33)">TM<span> </span></span></i><span style="margin:0px;font-family:Calibri, sans-serif;color:rgb(33, 33, 33)">for
 Consultants’ Conference. Physicians should claim only the credit commensurate with the extent of their participation in the activity.</span><span style="margin:0px;font-family:Calibri, sans-serif"></span></p>
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<h1 style="margin:0.05pt 0in 0in 11pt;font-family:"Times New Roman", serif"><u><span style="margin:0px;font-family:Calibri, sans-serif;color:rgb(33, 33, 33)">Disclosure Statement</span></u><span style="margin:0px;font-family:Calibri, sans-serif"></span></h1>
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<span style="margin:0px;font-family:Calibri, sans-serif;color:rgb(33, 33, 33)">The NYU Grossman School of Medicine adheres to ACCME accreditation requirements and policies, including the Standards for Commercial Support regarding industry support of continuing
 medical education. In order to resolve any identified Conflicts of Interest, disclosure information is provided during the planning process to ensure resolution of any identified conflicts. Disclosure of faculty and commercial relationships as well as the
 discussion of unlabeled or unapproved use of any drug, device or procedure by the faculty will be fully noted at the meeting.</span><span style="margin:0px;font-family:Calibri, sans-serif"></span></p>
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<span style="font-family:"Lucida Handwriting","Apple Chancery",cursive">Christine M. Stork, Pharm.D, DABAT, FAACT</span></div>
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<span style="font-family:"Lucida Handwriting","Apple Chancery",cursive">Professor, Department of Emergency Medicine</span></div>
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<span style="font-family:"Lucida Handwriting","Apple Chancery",cursive">Clinical Director, Upstate NY Poison Center</span></div>
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<span style="font-family:"Lucida Handwriting","Apple Chancery",cursive">Upstate Medical University</span></div>
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<span style="font-family:"Lucida Handwriting","Apple Chancery",cursive">Syracuse, NY</span></div>
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