[toxvtc] GHB

[Michael P. Keenan]

Also, this is what I was referring to with the GHB dosing timing. The case I had was a person who accidentally took the second dose very shortly after the first (she had messed up her alarm). The dosing is interesting - see package insert for more info.


2.3 Important Administration Instructions for All Patients

The total nightly dosage of Xyrem is divided into two doses. Prepare both doses of Xyrem prior to bedtime. Prior to ingestion, each dose of Xyrem should be diluted with approximately 1⁄4 cup (approximately 60 mL) of water in the empty pharmacy containers provided.

Take the first nightly dose of Xyrem at least 2 hours after eating [see Clinical Pharmacology (12.3)]. Take the second nightly dose 2.5 to 4 hours after the first dose.

Patients should take both doses of Xyrem while in bed and lie down immediately after dosing, and remain in bed following ingestion of each dose. Xyrem may cause patients to fall asleep abruptly without first feeling drowsy [see Adverse Reactions (6.2)]. Patients will often fall asleep within 5 minutes of taking Xyrem, and will usually fall asleep within 15 minutes, though the time it takes any individual patient to fall asleep may vary from night to night. Patients may need to set an alarm to awaken for the second dose. Rarely, patients may take up to 2 hours to fall asleep.

If the second dose is missed, that dose should be skipped and Xyrem should not be taken again until the next night. Both Xyrem doses should never be taken at one time.


WARNING: CENTRAL NERVOUS SYSTEM DEPRESSION and ABUSE AND MISUSE.

  *   Central Nervous System Depression
Xyrem (sodium oxybate) is a CNS depressant. In clinical trials at recommended doses, obtundation and clinically significant respiratory depression occurred in adult patients treated with Xyrem [see Warnings and Precautions (5.1)]. Many patients who received Xyrem during clinical trials in narcolepsy were receiving central nervous system stimulants [see Clinical Trials (14)].

-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://lists.upstate.edu/pipermail/toxvtc/attachments/20240308/9e2b6a90/attachment-0001.html>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: xyrem.en.USPI.pdf
Type: application/pdf
Size: 1207191 bytes
Desc: xyrem.en.USPI.pdf
URL: <http://lists.upstate.edu/pipermail/toxvtc/attachments/20240308/9e2b6a90/attachment-0001.pdf>