<html>
<head>
<meta http-equiv="Content-Type" content="text/html; charset=us-ascii">
<style type="text/css" style="display:none;"> P {margin-top:0;margin-bottom:0;} </style>
</head>
<body dir="ltr">
<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
Hi Nick,</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<br>
</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
I may have missed your point Monday but whether its acute or chronic, the antibody has to result in decreased tissue binding. In this study (children granted) of mix acute and chronic the earliest response was about 25 minutes, median time to complete response
was 90 minutes and everyone responded (at least that they had data) by 3 hours. I don't see where they compared acute v chronic in this paper.</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<br>
</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
Let me know tomorrow on fellow rounds if I missed the boat regarding your comment</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<br>
</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<br>
</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
Mike<br>
</div>
<div class="elementToProof">
<div style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);">
<br>
</div>
<div id="Signature">
<div>
<div><span style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0); background-color: rgb(255, 255, 255);">
<p style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: start; color: rgb(255, 255, 255);">
<span class="ContentPasted0" style="color: rgb(0, 0, 0);" lang="EN-US">Michael Hodgman MD</span><span class="ContentPasted0" lang="EN-US"><o:p class="ContentPasted0"></o:p></span></p>
<p style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: start; color: rgb(255, 255, 255);">
<span class="ContentPasted0" style="color: rgb(0, 0, 0);" lang="EN-US">Medical Toxicology, Upstate New York Poison Center</span><span class="ContentPasted0" lang="EN-US"><o:p class="ContentPasted0"></o:p></span></p>
<p style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: start; color: rgb(255, 255, 255);">
<span class="ContentPasted0" style="color: rgb(0, 0, 0);" lang="EN-US">Department of Emergency Medicine</span><span class="ContentPasted0" lang="EN-US"><o:p class="ContentPasted0"></o:p></span></p>
<p style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: start; color: rgb(255, 255, 255);">
<span class="ContentPasted0" style="color: rgb(0, 0, 0);" lang="EN-US">Upstate Medical University</span><span class="ContentPasted0" lang="EN-US"><o:p class="ContentPasted0"></o:p></span></p>
<p style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: start; color: rgb(255, 255, 255);">
<span class="ContentPasted0" style="color: rgb(0, 0, 0);">Syracuse, NY</span></p>
<br>
</span></div>
</div>
</div>
</div>
<div id="appendonsend"></div>
<hr style="display:inline-block;width:98%" tabindex="-1">
<div id="divRplyFwdMsg" dir="ltr"><font face="Calibri, sans-serif" style="font-size:11pt" color="#000000"><b>From:</b> toxvtc <toxvtc-bounces@lists.upstate.edu> on behalf of Nicholas Nacca <nicholasenacca@gmail.com><br>
<b>Sent:</b> Monday, June 5, 2023 2:11 PM<br>
<b>To:</b> toxvtc@lists.upstate.edu <toxvtc@lists.upstate.edu><br>
<b>Subject:</b> [toxvtc] attached</font>
<div> </div>
</div>
<div>
<div dir="ltr">Hey- 1976- i was close<br clear="all">
<div><br>
</div>
<span class="x_gmail_signature_prefix">-- </span><br>
<div dir="ltr" class="x_gmail_signature" data-smartmail="gmail_signature">
<div dir="ltr">
<div>Nicholas E. Nacca, MD<br>
Board Certified Emergency Medicine, Medical Toxicology & Addiction Medicine<br>
<br>
</div>
</div>
</div>
</div>
</div>
</body>
</html>