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Sorry I'm missing discussion today, but the lag your cases may have been due to ingestion of amygdalin alone? Figure 5 in the paper you forwarded shows the blood [cyanide] goes up really fast with ingestion of bitter almonds (amygdalin plus beta-glucosidase)
or cassava (linamarin plus beta-glucosidase) vs amygdalin alone. In that case the breakdown of the glycoside proceeds much more slowly without extrinsic beta-glucosidase packaged with the cyanogenic glycoside.
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Of course, chewing your seeds fully and carefully also helps this process!</div>
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Mike<br>
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<span style="color: rgb(0, 0, 0);">Michael Hodgman MD</span></p>
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<span style="color: rgb(0, 0, 0);">Medical Toxicology, Upstate New York Poison Center</span></p>
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<span style="color: rgb(0, 0, 0);">Upstate Medical University</span></p>
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<span style="color: rgb(0, 0, 0);">Syracuse, NY</span></p>
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<div id="divRplyFwdMsg" dir="ltr"><font face="Calibri, sans-serif" style="font-size:11pt" color="#000000"><b>From:</b> toxvtc <toxvtc-bounces@lists.upstate.edu> on behalf of Toomey, David <David_Toomey@URMC.Rochester.edu><br>
<b>Sent:</b> Wednesday, February 28, 2024 12:41 PM<br>
<b>To:</b> Ahmed Alsakha <AlsakhaA@upstate.edu>; Matthew Kolbeck <KolbeckM@upstate.edu>; Toxtvc List <toxvtc@lists.upstate.edu><br>
<b>Subject:</b> Re: [toxvtc] Fellow Rounds</font>
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<p class="x_MsoNormal">Fun paper on cyanogenic glycosides – serum CN peaks quite quickly, but for some reason the serum lactate we had in our amygdalin patients lagged behind this fairly significantly
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<p class="x_MsoNormal"><b>From:</b> toxvtc <toxvtc-bounces@lists.upstate.edu> <b>
On Behalf Of </b>Ahmed Alsakha<br>
<b>Sent:</b> Wednesday, February 28, 2024 12:08 PM<br>
<b>To:</b> Matthew Kolbeck <KolbeckM@upstate.edu>; Toxtvc List <toxvtc@lists.upstate.edu><br>
<b>Subject:</b> [EXT] Re: [toxvtc] Fellow Rounds</p>
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<p class="x_MsoNormal">Sorry we are running a bit late with guidelines review</p>
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<p class="x_MsoNormal">Should log in shortly </p>
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<p class="x_MsoNormal">Sincerely,</p>
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<p class="x_MsoNormal">Ahmed Alsakha</p>
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<p class="x_MsoNormal">Medical Toxicology Fellow </p>
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<p class="x_MsoNormal">SUNY Upstate Medical University </p>
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<p class="x_MsoNormal"><b><span style="color:black">From:</span></b><span style="color:black"> toxvtc <<a href="mailto:toxvtc-bounces@lists.upstate.edu">toxvtc-bounces@lists.upstate.edu</a>> on behalf of Matthew Kolbeck <<a href="mailto:KolbeckM@upstate.edu">KolbeckM@upstate.edu</a>><br>
<b>Sent:</b> Wednesday, February 28, 2024 11:42:18 AM<br>
<b>To:</b> Toxtvc List <<a href="mailto:toxvtc@lists.upstate.edu">toxvtc@lists.upstate.edu</a>><br>
<b>Subject:</b> [toxvtc] Fw: Fellow Rounds</span> </p>
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<p class="x_MsoNormal"><span style="font-size:12.0pt; font-family:"Arial",sans-serif; color:black">Matthew Kolbeck, MD</span><span style="font-size:12.0pt; color:black"></span></p>
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<p class="x_MsoNormal"><span style="font-size:12.0pt; font-family:"Arial",sans-serif; color:black">Medical Toxicology Fellow</span><span style="font-size:12.0pt; color:black"></span></p>
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