[LabUpdates] Laboratory Formulary Committee Updates - Neurology paraneoplastic autoantibody panel changes

[Matthew Elkins]

[cid:image001.jpg at 01D8C6A6.75AC0C30]

Medicine and laboratory testing are constantly changing. In an attempt to keep us all on the same page, the Laboratory Formulary Committee will be regularly sending out emails with recent updates and guidances.


Removal of Neurology Paraneoplastic Autoantibody Panel (MPAVL/MPAC1) from Epic 11/3/2022:  The Mayo neurology testing specialists strongly recommend that the paraneoplastic panel NOT be ordered, as that panel contains outdated antibody combinations and is not a panel they review/update for clinical utility. The other panels, including encephalopathy, epilepsy, and movement disorders, are more consistently updated with the most currently relevant/recommended antibody combinations. In particular, there have been studies that show that VGKC-complex antibodies (found only in the paraneoplastic panel) don't meet the criteria Mayo has set to be clinically relevant and therefore should not necessitate a paraneoplastic panel request.  VGKC-complex antibodies have been found to be non-specific, not able to direct a search for cancer, and not able to guide treatment or prognosis. Additionally, studies have shown that VGKC-complex antibodies provide little to no clinical value without LGI1 or CASPR2 positivity. Consequently, VGKC has been replaced by LGI1 and CASPR2 in the panels that Mayo updates.

If you have questions about what the most appropriate autoantibody panel is for your patient, please consult with Neurology.

For prior guidances, please visit https://urldefense.com/v3/__https://upstate0.sharepoint.com/sites/LaboratoryFormularyCommitteeLabchanges__;!!GobTDDpD7A!Nmu_sTIJNGhin6ROOliVixzBNrRykHbR7tMhy-Z6qeZJDpBEPRGpX5Xxi0QsJ0euXVa7dkqoda-MGxwKcWqBG9Mg5f1n$ <https://urldefense.com/v3/__https:/upstate0.sharepoint.com/sites/LaboratoryFormularyCommitteeLabchanges__;!!GobTDDpD7A!fMqwKEI3JlieL_eF-Vo4vMVj2PNzfXcL0GsxYMLCbL6cXpbRqzmyQKWIxbV1BBgJ8OlmOsFv$>




-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://lists.upstate.edu/pipermail/labupdates/attachments/20221101/e97373b1/attachment-0001.html>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image001.jpg
Type: image/jpeg
Size: 36981 bytes
Desc: image001.jpg
URL: <http://lists.upstate.edu/pipermail/labupdates/attachments/20221101/e97373b1/attachment-0001.jpg>