[toxnews] Toxicology Case Conference for March 4, 2021: Please note registration and time change (1-4 PM)

Mon Mar 1 06:24:48 EST 2021

Please join us in attending remotely the NYC Consultants Case Conference and Journal Club on March 4, 2021 from 1-4 PM. Please register independently (Information below)

 NYC PCC Grand Rounds and Consultants' Conference in March 2021.

Our grand rounds speaker will be Konstantin Ichtchenko and the title of his talk is: “Neuronal Delivery Of Therapeutic Antibodies For Treatment Of Botulism.”

Bio: Dr. Ichtchenko scientific interests are centered on understanding the molecular mechanisms controlling exocytosis and endocytosis at nerve termini, and in designing molecular tools that enable the individual steps and components mediating these events to be dissected. He is the Principal Investigator on the funded $7 million NIH/NIAID multi-center grant supporting research by developing atoxic Botulinum Neurotoxin (BoNT) derivatives that retain the targeting and intracellular trafficking of wild type BoNT, thereby enabling delivery of the atoxic BoNT light chain (LC) to the neuronal cytosol. Dr. Ichtchenko is a widely acknowledged expert on protein engineering, and the molecular mechanisms of inter-neuronal and neuromuscular communication. He was responsible for the first successful expression and crystallographic characterization of the LDL receptor extracellular domain, done in collaboration with three Nobel laureates. Dr. Ichtchenko has also made major contributions to the discovery of neuroligins, molecules that are involved in synaptogenesis, and with yet another Nobel laureate, to the pre- and post-synaptic mechanisms of action of alpha-latrotoxin (black widow spider toxin). He is currently Assistant Professor in the Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine.

Please see the flyer below for more details.
Click here<https://urldefense.com/v3/__https://survey.alchemer.com/s3/5971719/Consultant-Conference?eventid=*20a1Q4V00002W4OaXUAV*20&Programname=NYC*20Poison*20Contol*20Center__;JSUlJSU!!GobTDDpD7A!c6fDmBV6uvnPgE0njKgZ56XIUoeyiW790MB_Di0pgy94R_ke7envegc8xarT4BIf$> to register for the conference.

<https://urldefense.com/v3/__https://survey.alchemer.com/s3/5971719/Consultant-Conference?eventid=*20a1Q4V00002W4OaXUAV*20&Programname=NYC*20Poison*20Contol*20Center__;JSUlJSU!!GobTDDpD7A!c6fDmBV6uvnPgE0njKgZ56XIUoeyiW790MB_Di0pgy94R_ke7envegc8xarT4BIf$>
For any NYU participants who wish to receive CME credit, please register for the meeting with your NYU email address.

Thank you very much!

Mark

[cid:db2fddc2-cee9-4f56-96d8-81a5a55610b1]

Consultants' Conference is a monthly meeting attended by medical toxicologists, emergency physicians, pharmacists and other learners from all over the Northeast. It is an educational activity in which the Consultants (renowned experts in various medical specialties) provide insight into the analysis and approach to the diagnosis and treatment of interesting toxicologic cases. The cases are presented mostly by the NYU Toxicology fellows in training, but anyone can present their case if deemed appropriate. Learners of all levels can benefit from the rich and often dynamic discourse.

The next NYC PCC Grand Rounds and Consultants’ Conference will be held on Thursday, March 4, 2021. Grand Rounds will occur from 1:00 to 1:45 p.m. EST. The topic and speaker will be:

“Neuronal Delivery of Therapeutic Antibodies for the Treatment of Botulism”

Konstantin Ichtchenko

Assistant Professor

Department of Biochemistry and Molecular Pharmacology

NYU Grossman School of Medicine

Consultants’ Conference will take place shortly after the Grand Rounds lecture is over starting at 2 p.m. EST and ending at 4 p.m. EST.

We will be broadcasting both the Grand Rounds lecture and Consultants’ Conference via the same link on WebEx and there WILL NOT be a live conference at the Public Health Laboratory. Please click here<https://urldefense.com/v3/__https://survey.alchemer.com/s3/5971719/Consultant-Conference?eventid=*20a1Q4V00002W4OaXUAV*20&Programname=NYC*20Poison*20Contol*20Center__;JSUlJSU!!GobTDDpD7A!c6fDmBV6uvnPgE0njKgZ56XIUoeyiW790MB_Di0pgy94R_ke7envegc8xarT4BIf$> to register to download the WebEx outlook file.

Please Note: If you would like to receive this monthly announcement on a regular basis, please register for the conference at the link above, even if you are unable to attend.

Cases to be discussed for Consultants’ Conference include:

1.        A 35-year-old male patient with no known significant past medical history presents to the ED complaining of palpitations after using an illicit substance. He is admitted to the hospital for persistent altered mental status and a NSTEMI. Three days after hospital admission, he is noted to have a flat affect along with increased tone; a medical toxicology consultation is requested by the medical team. His vital signs at this time are: BP, 120/84; HR, 108 beats/min; RR, 18 breaths/minute; T, 35.6°C; O2 Sat, 99% (RA).

2.        A 6-year-old child with prior simple febrile seizures presents to the ED for altered mental status after a suspected ingestion of a product being used as a sleep aid. In the ED, the patient is noted to have a 3-minute “seizure-like” event with rigid extremities and drooling, followed by a brief period of unresponsiveness. The child’s vital signs after the seizure are: BP, 93/45 mm Hg; HR, 97 beats/minute; RR, 13 breaths/minute; T, 37.6°C, O2 Sat, 98% (room air).

3.        An 18-year-old female patient presents to the ED with altered mental status after an intentional suicidal overdose of her own medications. Her vital signs on presentation are: BP, 156/74 mm Hg; HR, 104 beats/minute; RR, 19 breaths/minute; T, 37.1°C; Os Sat, 100% (room air). Approximately 24 hours later, she is noted to have a transient non-sustained wide complex tachycardia seen on telemetry monitoring.

Mark K. Su, MD, MPH

Director, New York City Poison Control Center

Jointly Provided by the NYU Grossman School of Medicine and the Poison Control Center.

Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of the NYU School of Medicine and the Poison Control Center. The NYU Grossman School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation Statement

The NYU Grossman School of Medicine designates both of these as live activities for a maximum of 0.75 AMA PRA Category 1 CreditsTM for Toxicology Grand Rounds and 2 AMA PRA Category 1 CreditsTM for Consultants’ Conference. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure Statement

The NYU Grossman School of Medicine adheres to ACCME accreditation requirements and policies, including the Standards for Commercial Support regarding industry support of continuing medical education. In order to resolve any identified Conflicts of Interest, disclosure information is provided during the planning process to ensure resolution of any identified conflicts. Disclosure of faculty and commercial relationships as well as the discussion of unlabeled or unapproved use of any drug, device or procedure by the faculty will be fully noted at the meeting.

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Christine M. Stork, Pharm.D, DABAT, FAACT
Professor, Department of Emergency Medicine
Clinical Director, Upstate NY Poison Center
Upstate Medical University
Syracuse, NY
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