[toxvtc] Fellow Rounds

[Michael Hodgman]

Sorry I'm missing discussion today, but the lag your cases may have been due to ingestion of amygdalin alone? Figure 5 in the paper you forwarded shows the blood [cyanide] goes up really fast with ingestion of bitter almonds (amygdalin plus beta-glucosidase) or cassava (linamarin plus beta-glucosidase) vs amygdalin alone. In that case the breakdown of the glycoside proceeds much more slowly without extrinsic beta-glucosidase packaged with the cyanogenic glycoside.
Of course, chewing your seeds fully and carefully also helps this process!

Mike


Michael Hodgman MD

Medical Toxicology, Upstate New York Poison Center

Department of Emergency Medicine

Upstate Medical University

Syracuse, NY

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From: toxvtc <toxvtc-bounces at lists.upstate.edu> on behalf of Toomey, David <David_Toomey at URMC.Rochester.edu>
Sent: Wednesday, February 28, 2024 12:41 PM
To: Ahmed Alsakha <AlsakhaA at upstate.edu>; Matthew Kolbeck <KolbeckM at upstate.edu>; Toxtvc List <toxvtc at lists.upstate.edu>
Subject: Re: [toxvtc] Fellow Rounds


Fun paper on cyanogenic glycosides – serum CN peaks quite quickly, but for some reason the serum lactate we had in our amygdalin patients lagged behind this fairly significantly







From: toxvtc <toxvtc-bounces at lists.upstate.edu> On Behalf Of Ahmed Alsakha
Sent: Wednesday, February 28, 2024 12:08 PM
To: Matthew Kolbeck <KolbeckM at upstate.edu>; Toxtvc List <toxvtc at lists.upstate.edu>
Subject: [EXT] Re: [toxvtc] Fellow Rounds



Sorry we are running a bit late with guidelines review



Should log in shortly



Sincerely,

Ahmed Alsakha

Medical Toxicology Fellow

SUNY Upstate Medical University

________________________________

From: toxvtc <toxvtc-bounces at lists.upstate.edu<mailto:toxvtc-bounces at lists.upstate.edu>> on behalf of Matthew Kolbeck <KolbeckM at upstate.edu<mailto:KolbeckM at upstate.edu>>
Sent: Wednesday, February 28, 2024 11:42:18 AM
To: Toxtvc List <toxvtc at lists.upstate.edu<mailto:toxvtc at lists.upstate.edu>>
Subject: [toxvtc] Fw: Fellow Rounds



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SUNY Upstate Medical University

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